Our lab is at
Briggs 178-180
Phone: 530-752-8337
System and computational modeling of cytoskeletal dynamics, cell motility, mitosis
Ours is a 'dry' lab. We use mathematical and computer modeling, theoretical
biophysics and system biology tools to develop and simulate cytoskeletal processes. We collaborate
extensively with experimentalists. Current collaborators are:
Julie Theriot lab (Stanford), Pat Wadsworth lab (U Mass), Rick Horwitz lab (UVa),
Kinneret Keren lab (Technion), Vladimir Rodionov lab (U Conn), Daniela Cimini lab (Virginia Tech),
Steve Gross lab (UC Irvine), Dyche Mullins lab (UCSF), Jon Scholey and Scott Dawson labs (UC Davis)
The research of our lab focusses on the molecular mechanisms of regulation
and mechanics of actin- and microtubule-motor assemblies, cell migration and mitosis.
Our major projects are:
1. Actin-myosin and adhesion dynamics, flow of cytoplasm, shape of crawling keratocyte cells.
2. Self-assembly and mechanics of the mitotic spindle.
3. Symmetry break and motility in biomimetric actin systems.
4. Microtubule-motor bundles and applications to platelet morphogenesis, Giardia, axons.
5. Multiple molecular motor behavior.
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