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Understanding Scarring with Mathematics
Applied Math| Speaker: | John Dallon, Brigham Young University |
| Location: | 693 Kerr |
| Start time: | Fri, May 17 2002, 4:10PM |
Orientation of extracellular matrix fibers in the skin is a key ingredient of tissue appearance and function, and differences in fiber alignment are one of the main distinctions between scar tissue and normal skin. In this talk, I will discuss two mathematical models for alignment of collagen fibers and the fibroblast cells that remodel them. I will begin with a spatially uniform model of integrodifferential equations and then discuss a model with discrete cells. The effects of TGFb are incorporated in the second model and various conclusions are drawn about its ability to alter scar formation.
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