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A Numerical Method to Investigate the Effects of Changing Cell Morphologies on Biochemical Signaling Networks
Mathematical Biology| Speaker: | Wanda Strychalski, University of North Carolina |
| Location: | 2112 MSB |
| Start time: | Thu, Jan 29 2009, 11:00AM |
Description
Signaling networks regulate cellular responses to environmental stimuli through
cascades of protein interactions. External signals can trigger cells to
polarize and move in a specific direction and maintain spatially localized
activity of proteins. To investigate the effects of morphological changes on
intracellular signaling, we implement a numerical scheme consisting of a cut
cell finite volume spatial discretization coupled with level set methods.
Applications of this method to models of signaling networks in time-dependent
geometries are then discussed. This is joint work with David Adalsteinsson and
Timothy Elston.