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Correlating DNA sequence with the formation of Z-DNA: insights gained from single molecule experiments

Mathematical Biology

Speaker: Paul Pease, Microbiology and Molecular Genetics, UC Davis
Related Webpage:,paul.htm
Location: 2112 MSB
Start time: Mon, Feb 2 2015, 3:10PM

While DNA normally exists as a right-handed double helix known as B-DNA, under certain conditions it can actually adopt a left-handed conformation known as Z-DNA. The probabilty of forming Z-DNA depends on the DNA sequence and other factors that make the B-Z transition a potentially useful switch for controlling biological processes such as gene expression. Here we use a single-molecule assay to make high resolution measurements of the B-Z transition. This seminar highlights the progress that has been made through application of quantitative methods including single-molecule biophysics, theoretical modeling and bioinformatics.

Please let Mariel Vazquez ( know if you would like to meet with the speaker, or join him for dinner.