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Dynamical mechanisms by which pharmaceutical drugs affect the propensity for cardiac arrhythmias

Student-Run Applied & Math Seminar

Speaker: Steffen Docken, UC Davis
Location: 2112 MSB
Start time: Wed, May 25 2016, 11:10AM

One of the leading causes for pharmaceutical drugs being removed from the market is the induction of cardiac arrhythmias, which can lead to sudden cardiac arrest. Researchers have begun to mathematically model the effects of drugs on electrical signaling in the heart. However, most of these models are very detailed and complicated, which makes it difficult to uncover the underlying mechanisms affecting the propensity for arrhythmias. In this talk, I will discuss both differential equation models of electrical signaling in the heart and how these models are adjusted to include the affects of drugs. I will also describe how I plan to use simpler versions of these models along with singular perturbation theory and numerical simulations to better understand what causes some drugs to be pro-arrhythmic.

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